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    Temporal representation and event dating

    This represents a promising alternative for large surveys requiring an automatic methodology to establish a timeline of duplication events and that are usually limited to the use of d S, which presents known limitations such as a fast saturation of the signal.However, both measures have never been compared in a common framework.Time is a component quantity of various measurements used to sequence events, to compare the duration of events or the intervals between them, and to quantify rates of change of quantities in material reality or in the conscious experience.Two contrasting viewpoints on time divide prominent philosophers.

    Besides the need for more research in temporal granularity, fuzzy time, temporal contradiction, intermittent events and uncertainty, broad areas for future research include enhancing functions of current MLP systems on processing temporal information, incorporating medical knowledge into temporal reasoning systems, resolving coreference, integrating narrative data with structured data and evaluating these systems.Due to its elementary quality, time is widely discussed in philosophy, physics, and aesthetics.St Augustine claims that time is hard to grasp even though one has an intuitional notion of it (Augustine 1992: 154).This is not only one of the most prominent commonplaces referred to throughout discussions about time, but also makes the inherent tension in time apparent, i.e. Against the background of ancient ideas of time as “a number of changes in respect of the before and after” (Aristotle [1983] 2006: 44 [Physics IV.11, 219b]), Kant’s philosophy of transcendental aesthetics sets a new benchmark by understanding time as both an “empirical reality” and “transcendental ideality” (Kant [1781/1787] 1998: 181 [A35–36/B52]).Kant argues that time is an a priori that is presupposed in all human experience.These substitutions can be classified as non-synonymous or synonymous depending on whether the nucleotide change results in a amino acid substitution in the encoded protein.Since synonymous substitutions are considered relatively free of selective pressures, at least at the protein level, these are often assumed to accumulate with time in a linear fashion that depends on the species generation time and mutation rates.One view is that time is part of the fundamental structure of the universe—a dimension independent of events, in which events occur in sequence.Isaac Newton subscribed to this realist view, and hence it is sometimes referred to as Newtonian time.Results: Topology-based placement of duplications on a relative time scale corresponding to periods between speciation events were found to be highly consistent, providing the same placement for 67–84% of a reliable set of gene pairs duplicated in a single event.For recent evolutionary periods, d S and topological measures showed a strong correlation.Time is used to define other quantities—such as velocity—so defining time in terms of such quantities would result in circularity of definition.An operational definition of time, wherein one says that observing a certain number of repetitions of one or another standard cyclical event (such as the passage of a free-swinging pendulum) constitutes one standard unit such as the second, is highly useful in the conduct of both advanced experiments and everyday affairs of life.Previous work in processing time with clinical narrative data includes processing time in clinical reports, modeling textual temporal expressions in clinical databases, processing time in clinical guidelines, and building time standards for data exchange and integration.

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